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1

Design, synthesis and antiproliferative activity of tripentones: A new series of antitubulin agents

Vincent Lisowski, Cécile Enguehard, Jean-Charles Lancelot, Daniel-Henri Caignard, Stéphanie Lambel, Stéphane Leonce, Alain Pierre, Ghanem Atassi, Pierre Renard, Sylvain Rault

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 162 KB

english, 2001

2

Design, Synthesis, and Evaluation of Novel Thienopyrrolizinones as Antitubulin Agents

Kraus-Berthier, Laurence, Sopková-de Oliveira Santos, Jana, Pierré, Alain, Atassi, Ghanem, Caignard, Daniel-Henri, Renard, Pierre, Rault, Sylvain, Lisowski, Vincent, Léonce, Stéphane

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 269 KB

english, 2004

3

Antitumor activity of quassinoids from Hannoa klaineana

Lumonadio, Luyengi, Atassi, Ghanem, Vanhaelen, Maurice, Vanhaelen-Fastre, Renee

Journal:

Journal of Ethnopharmacology

Year:

1991

Language:

english

File:

PDF, 377 KB

english, 1991

4

Induction of Cyclin E and Inhibition of DNA Synthesis by the Novel Acronycine Derivative S23906-1 Precede the Irreversible Arrest of Tumor Cells in S Phase Leading to Apoptosis

Léonce, Stéphane, Pérez, Valérie, Lambel, Stéphanie, Peyroulan, Delphine, Tillequin, François, Michel, Sylvie, Koch, Michel, Pfeiffer, Bruno, Atassi, Ghanem, Hickman, John A, Pierré, Alain

Journal:

Molecular Pharmacology

Year:

2001

Language:

english

File:

PDF, 302 KB

english, 2001

5

Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in human neuroblastomas

Langer, Ingrid, Vertongen, Pascale, Perret, Jason, Fontaine, Jeanine, Atassi, Ghanem, Robberecht, Patrick

Journal:

Medical and Pediatric Oncology

Year:

2000

Language:

english

File:

PDF, 406 KB

english, 2000

6

Up-regulated expression of the β3 integrin and the 92-kDa gelatinase in human HT-144 melanoma cell tumors grown in nude mice

Valérie Gouon, Gordon C. Tucker, Laurence Kraus-Berthier, Ghanem Atassi, Nelly Kieffer

Journal:

International Journal of Cancer

Year:

1996

Language:

english

File:

PDF, 1.41 MB

english, 1996

7

Tumor Inhibiting Properties of Stereoisomeric [1,2-Bis(3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-Complexes, Part I: Synthesis

Margaretha Jennerwein, Ronald Gust, Richard Müller, Helmut Schönenberger, Jürgen Engel, Martin R. Berger, Dietrich Schmähl, Siegfried Seeber, Reinhardt Osieka, Ghanem Atassi, Danièle Maréchal-De Bock

Journal:

Archiv der Pharmazie

Year:

1989

Language:

english

File:

PDF, 346 KB

english, 1989

8

Tumor Inhibiting Properties of Stereoisomeric [1,2-Bis (3-hydroxyphenyl)ethylenediamine]dichloroplatinum(II)-Complexes, Part II: Biological Properties

Margaretha Jennerwein, Ronald Gust, Richard Müller, Helmut Schönenberger, Jürgen Engel, Martin R. Berger, Dietrich Schmähl, Siegfried Seeber, Reinhanidt Osieka, Ghanem Atassi, Danièle Maréchal-De Bock

Journal:

Archiv der Pharmazie

Year:

1989

File:

PDF, 509 KB

1989

9

A new method for the purification of cytochrome-P450 from human liver microsomes

Majed Isa, Jean Cumps, Claudine Fossoul, Ghanem Atassi

Journal:

Biomedical Chromatography

Year:

1992

Language:

english

File:

PDF, 290 KB

english, 1992

10

Synthesis, Characterisation and Anti-Tumour Activity of Bis(Polyfluoroalkyl)Tin Dihalides

Ludo De Clercq, Rudolph Willem, Marcel Gielen, Ghanem Atassi

Journal:

Bulletin des Sociétés Chimiques Belges

Year:

1984

Language:

english

File:

PDF, 310 KB

english, 1984

11

ChemInform Abstract: Synthesis and Cytotoxic Activity of 1-Alkoxy- and 1-Amino-2-hydroxy-1,2-dihydroacronycine Derivatives.

Prokopios Magiatis, Sofia Mitaku, Alexios-Leandros Skaltsounis, Francois Tillequin, Michel Koch, Alain Pierre, Ghanem Atassi

Journal:

Year:

1999

File:

PDF, 32 KB

1999

12

ChemInform Abstract: Synthesis and Conformational Analysis of Some New Pyrano[2,3-c]xanthen-7-one and Pyrano[3,2-b]xanthen-6-one Derivatives with Cytotoxic Activity.

Konstantinos Ghirtis, Nicole Pouli, Panagiotis Marakos, Alexios-Leandros Skaltsounis, Stephane Leonce, Daniel H. Caignard, Ghanem Atassi

Journal:

Year:

2000

File:

PDF, 30 KB

2000

13

ChemInform Abstract: Synthesis and Cytotoxic Activity of 11-Nitro and 11-Amino Derivatives of Acronycine and 6-Demethoxyacronycine.

Abdelhakim Elomri, Sylvie Michel, Michel Koch, Elisabeth Seguin, Francois Tillequin, Alain Pierre, Ghanem Atassi

Journal:

Year:

2000

File:

PDF, 30 KB

2000

14

ChemInform Abstract: Design, Synthesis and Biological Activity of 7-O-(4-O-Acetyl-3-iodo-2,3,6-trideoxy-α-L-arabino-hexopyranosyl) daunomycinone and 7-O-(3-Chloro-2,3,6-trideoxy-4-O-propanoyl-α-L-lyxo-hexopyranosyl) daunomycinone.

Nectarios Aligiannis, Nicole Pouli, Panagiotis Marakos, Sofia Mitaku, Alexios-Leandros Skaltsounis, Stephane Leonce, Alain Pierre, Ghanem Atassi

Journal:

Year:

2000

File:

PDF, 33 KB

2000

15

ChemInform Abstract: Synthesis and Cytotoxic Activity of 2-Dialkylaminoethylamino Substituted Xanthenone and Thioxanthenone Derivatives.

Ioannis Kostakis, Konstantinos Ghirtis, Nicole Pouli, Panagiotis Marakos, Alexios-Leandros Skaltsounis, Stephane Leonce, Daniel H. Caignard, Ghanem Atassi

Journal:

Year:

2001

File:

PDF, 30 KB

2001

16

ChemInform Abstract: Access to New Cytotoxic Bisindole Alkaloids by a Modified Borch Reductive Amination Process.

Guy Lewin, Corinne Schaeffer, Reynald Hocquemiller, Edgar Jacoby, Stephane Leonce, Alain Pierre, Ghanem Atassi

Journal:

Year:

2001

File:

PDF, 31 KB

2001

17

ChemInform Abstract: Synthesis of a Novel Series of Cytotoxic Bisindole Alkaloids (III).

Marion Raoul, Corinne Schaeffer, Stephane Leonce, Alain Pierre, Ghanem Atassi, Reynald Hocquemiller, Guy Lewin

Journal:

Year:

2001

File:

PDF, 27 KB

2001

18

ChemInform Abstract: General Synthesis of α-Substituted 3-Bisaryloxy Propionic Acid Derivatives as Specific MMP Inhibitors.

Anne-Marie Chollet, Thierry Le Diguarher, Lynne Murray, Marc Bertrand, Gordon C. Tucker, Massimo Sabatini, Alain Pierre, Ghanem Atassi, Jacqueline Bonnet, Patrick Casara

Journal:

Year:

2001

File:

PDF, 38 KB

2001

19

ChemInform Abstract: Design and Synthesis of Some New Pyranoxanthenones with Cytotoxic Activity.

Konstantinos Ghirtis, Nicole Pouli, Panagiotis Marakos, Alexios-Leandros Skaltsounis, Stephane Leonce, Ghanem Atassi, Daniel H. Caignard

Journal:

Year:

2001

File:

PDF, 30 KB

2001

20

ChemInform Abstract: Synthesis and Cytotoxic Activity of Benzopyranoxanthone Analogues of Benzo[b]acronycine and Psorospermine.

Chavalit Sittisombut, Nadine Costes, Sylvie Michel, Michel Koch, Francois Tillequin, Bruno Pfeiffer, Pierre Renard, Alain Pierre, Ghanem Atassi

Journal:

Year:

2001

File:

PDF, 33 KB

2001

21

ChemInform Abstract: Synthesis and Cytotoxic Activity of Benzophenanthrolinone Analogues of Acronycine.

Jean-Bernard Bongui, Abdelhakim Elomri, Elisabeth Seguin, Francois Tillequin, Bruno Pfeiffer, Pierre Renard, Alain Pierre, Ghanem Atassi

Journal:

Year:

2002

File:

PDF, 31 KB

2002

22

ChemInform Abstract: An Efficient Method for the Preparation of Antitumoral α-Keto-imines Benzyldihydroisoquinolines by Selective Benzylic Oxidation with C/Pd in Acetonitrile.

Inmaculada Andreu, Nuria Cabedo, Ghanem Atassi, Alain Pierre, Daniel H. Caignard, Pierre Renard, Diego Cortes, Almudena Bermejo

Journal:

Year:

2002

File:

PDF, 33 KB

2002

23

ChemInform Abstract: Synthesis and Cytotoxic Activity of Isoacronycine and Its Derivatives.

Prokopios Magiatis, Sofia Mitaku, Alain Pierre, Ghanem Atassi

Journal:

Year:

2002

File:

PDF, 29 KB

2002

24

Design and synthesis of some new pyranoxanthenones with cytotoxic activity

Konstantinos Ghirtis, Nicole Pouli, Panagiotis Marakos, Alexios-Leandros Skaltsounis, Stephane Leonce, Ghanem Atassi, Daniel H. Caignard

Journal:

Journal of Heterocyclic Chemistry

Year:

2001

Language:

english

File:

PDF, 79 KB

english, 2001

25

Synthesis and biological activity of 4′-azido- and 4′-trifluoracetamido-3′-chloro-3′-deamino-4′-deoxydaunorubicin

Nectarios Aligiannis, Nicole Pouli, Panagiotis Marakos, Alexios-Leandros Skaltsounis, Stephane Leonce, Alain Pierre, Ghanem Atassi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 239 KB

english, 1996

26

Investigations into the antitumour activity of organotin compounds. 2. Diorganotin dihalide and dipseudohalide complexes

Alan J. Crowe, Peter J. Smith, Ghanem Atassi

Journal:

Inorganica Chimica Acta

Year:

1984

Language:

english

File:

PDF, 461 KB

english, 1984

27

An efficient method for the preparation of antitumoral α-keto-imines benzyldihydroisoquinolines by selective benzylic oxidation with C/Pd in acetonitrile

Inmaculada Andreu, Nuria Cabedo, Ghanem Atassi, Alain Pierre, Daniel H Caignard, Pierre Renard, Diego Cortes, Almudena Bermejo

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 99 KB

english, 2002

28

Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle

Ying Li, Feng Shan, Jin-Ming Wu, Guang-Shao Wu, Jian Ding, Dong Xiao, Wei-Yi Yang, Ghanem Atassi, Stéphane Léonce, Daniel-Henri Caignard, Pierre Renard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 177 KB

english, 2001

29

Synthesis of a novel series of cytotoxic bisindole alkaloids

Marion Raoul, Corinne Schaeffer, Stéphane Léonce, Alain Pierré, Ghanem Atassi, Reynald Hocquemiller, Guy Lewin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 164 KB

english, 2001

30

General synthesis of α-substituted 3-bisaryloxy propionic acid derivatives as specific mmp inhibitors

Anne-Marie Chollet, Thierry Le Diguarher, Lynne Murray, Marc Bertrand, Gordon C Tucker, Massimo Sabatini, Alain Pierré, Ghanem Atassi, Jacqueline Bonnet, Patrick Casara

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 194 KB

english, 2001

31

Synthesis and antiproliferative activity of a cyclic analog of dolastatin 10

Joël Poncet, Laurent Hortala, Magali Busquet, Françoise Guéritte-Voegelein, Sylvie Thoret, Alain Pierré, Ghanem Atassi, Patrick Jouin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 190 KB

english, 1998

32

2,2-Dimethyl-2H-anthra[2,3-b]pyran-6,11-diones: a new class of cytotoxic compounds

Eleni Melliou, Prokopios Magiatis, Sofia Mitaku, Alexios-Leandros Skaltsounis, Alain Pierré, Ghanem Atassi, Pierre Renard

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 413 KB

english, 2001

33

Synthesis, cytotoxic activity, NMR study and stereochemical effects of some new pyrano[3,2-b]thioxanthen-6-ones and Pyrano[2,3-c]thioxanthen-7-ones

Ioannis K. Kostakis, Nicole Pouli, Panagiotis Marakos, Emmanuel Mikros, Alexios-Leandros Skaltsounis, Stephane Leonce, Ghanem Atassi, Pierre Renard

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 311 KB

english, 2001

34

Synthesis and cytotoxicity of dihydroartemisinin ethers containing cyanoarylmethyl group

Ying Li, Jin-Ming Wu, Feng Shan, Guang-Shao Wu, Jian Ding, Dong Xiao, Jia-Xian Han, Ghanem Atassi, Stéphane Leonce, Daniel-Henri Caignard, Pierre Renard

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 225 KB

english, 2003

35

Ineffectiveness of inicarone, a fibrinolytic agent, alone or in combination with chemotherapeutic agents on spontaneously metastasizing murine tumours

Patrick Dumont, Ghanem Atassi, Robert Jager

Journal:

Clinical and Experimental Metastasis

Year:

1983

Language:

english

File:

PDF, 502 KB

english, 1983

36

Preclinical antitumor activity of batracylin (NSC 320846)

Jacqueline Plowman, Kenneth D. Paull, Ghanem Atassi, Steadman D. Harrison, Donald J. Dykes, Hans J. Kabbe, V. L. Narayanan, Omar C. Yoder

Journal:

Investigational New Drugs

Year:

1988

Language:

english

File:

PDF, 471 KB

english, 1988

37

In vitrocytotoxicity of S16020-2, a new olivacine derivative

Stéphane Léonce, Valérie Perez, Marie-Rose Casabianca-Pignede, Monique Anstett, Emile Bisagni, Alain Pierré, Ghanem Atassi

Journal:

Investigational New Drugs

Year:

1996

Language:

english

File:

PDF, 869 KB

english, 1996

38

Antineoplastic activity of ASTA Z 7557 (NSC-345842, INN mafosfamide) on transplantable murine tumors

Ghanem Atassi, Peter Hilgard, Joarg Pohl

Journal:

Investigational New Drugs

Year:

1984

Language:

english

File:

PDF, 287 KB

english, 1984

39

In vivo evidence of complete circumvention of vincristine resistance by a new triazinoaminopiperidine derivative S 9788 in P388/VCR leukemia model

Suzy Cros, Nicolas Guilbaud, Maryse Berlion, Theresa Dunn, Gilbert Regnier, Alain Dhainaut, Ghanem Atassi, Jean-Pierre Bizzari

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1992

Language:

english

File:

PDF, 419 KB

english, 1992

40

Relationship between the cellular accumulation and the cytotoxicity of S12363, a new vinca alkaloid derivative

Alain Pierré, Valérie Pérez, Stéphane Léonce, Jean A. Boutin, Dominique Saint-Dizier, Patrick Hautefaye, Gilbert Lavielle, Ghanem Atassi

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1992

Language:

english

File:

PDF, 820 KB

english, 1992

41

In vitroandin vivocircumvention of multidrug resistance by Servier 9788, a novel triazinoaminopiperidine derivative

Alain Pierré, Theresa A. Dunn, Laurence Kraus-Berthier, Stéphane Léonce, Dominique Saint-Dizier, Gilbert Régnier, Alain Dhainaut, Maryse Berlion, Jean-Pierre Bizzari, Ghanem Atassi

Journal:

Investigational New Drugs

Year:

1992

Language:

english

File:

PDF, 863 KB

english, 1992

42

Selection of a histidine-containing inhibitor of gelatinases through deconvolution of combinatorial tetrapeptide libraries

Gilles Ferry, Jean A. Boutin, Ghanem Atassi, Jean-Luc Fauchère, Gordon C. Tucker

Journal:

Molecular Diversity

Year:

1997

Language:

english

File:

PDF, 1.70 MB

english, 1997

43

Comparison of the pharmacological profile of an olivacine derivative and a potential prodrug

Laurence Kraus-Berthier, Nicolas Guilbaud, Stéphane Léonce, Tracy Parker, Patrick Genissel, Claude Guillonneau, Solo Goldstein, Ghanem Atassi, Alain Pierré

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2002

Language:

english

File:

PDF, 176 KB

english, 2002

44

Synthesis, characterization and antitumour activity of 7,7-di-n-butyl-5,9-dioxo-6,8-dioxa-7-stanna-spiro[3,5]nonane, a di-n-butyltin(IV) analog of “paraplatin”, and of a series of di-n-butyltin(IV) derivatives of mono- and disubstltuted malonic acids

Marcel Gielen, Muriel Mélotte, Ghanem Atassi, Rudolph Willem

Journal:

Year:

1989

Language:

english

File:

PDF, 513 KB

english, 1989

45

Synthesis and cytotoxicity of artemisinin derivatives containing cyanoarylmethyl group

Jin-Ming Wu, Feng Shan, Guang-Shao Wu, Ying Li, Jian Ding, Dong Xiao, Jia-Xian Han, Ghanem Atassi, Stéphane Leonce, Daniel-Henri Caignard, Pierre Renard

Journal:

European Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 147 KB

english, 2001

46

In Situ Activity of Gelatinases during Lewis Lung Carcinoma Progression

GORDON C. TUCKER, GILLES FERRY, STÉPHANE PROVENT, GHANEM ATASSI

Journal:

Annals of the New York Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 748 KB

english, 1999

47

The effect of extracellular pH on angiogenesisin vitro

Mike F. Burbridge, David C. West, Ghanem Atassi, Gordon C. Tucker

Journal:

Year:

1999

Language:

english

File:

PDF, 176 KB

english, 1999

48

Synthesis and Anti-proliferative Activity of 2-Hydroxy-l,2-dihydroacronycine Glycosides

Sofia Mitaku, Alexios-Léandros Skaltsounis, François Tillequin, Michel Koch, Yves Rolland, Alain Pierré, Ghanem Atassi

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 856 KB

1996

49

Characterization of Alkylating Versus Intercalating Anticancer Drug-Induced Effects on Cell Survival, Cell Cycle Kinetic and Morphonuclear Pattern of Three Neoplastic Cells Lines Growingin Vitro

Olivier Pauwels, Robert Kiss, Jean-Lambert Pasteels, Ghanem Atassi

Journal:

Pharmaceutical Research

Year:

1995

File:

PDF, 1.45 MB

1995

50

A characterization of the activity of α-1,3,5-triglycidyl-s-triazinetrione, a novel antineoplastic compound

Federico Spreafico, Ghanem Atassi, Stefania Filippeschi, Carmela Malfiore, Serena Noseda, Donatella Boschetti

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1980

Language:

english

File:

PDF, 476 KB

english, 1980